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Several trials have suggested a modest benefit to adding zoledronic acid to the adjuvant therapy in women who are already menopausal or in whom menopause is induced. Patients who are HBsAg positive can have a flare of hepatitis while on chemotherapy. Thus, the dose-related risk implications for women are considered acceptable. Patients should be referred to radiation oncology in such circumstances. The pathologist should mark the margins of the specimen with silver nitrate or India ink and, if this has not already been done, send a portion of tumour for receptor studies. MRI has proven valuable in detecting and staging breast cancer, particularly when other imaging studies mammography, ultrasound, etc. The ability to detect breast lesions using CAD is shown in the two tables below:.

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